Definitive chemoradiation in patients with inoperable oesophageal carcinoma

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Safety and efficacy of radiation and chemoradiation in patients over 70 years old with inoperable esophageal squamous cell carcinoma

The aim of the present study was to perform a retrospective analysis to investigate the outcome and toxicity of radiation (RT) and chemoradiation (CRT) in elderly, inoperable patients >70 years old. Between 2003 and 2012, 1,024 patients with squamous cell carcinoma (SCC) of the esophagus were treated at the Department of Thoracic Cancer, West China Hospital (Chengdu, China). Of these patients, ...

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Clinical outcomes in elderly patients with human papillomavirus-positive squamous cell carcinoma of the oropharynx treated with definitive chemoradiation therapy.

BACKGROUND The benefit of combined chemoradiation in elderly patients with human papillomavirus (HPV)-positive locally advanced oropharyngeal squamous cell carcinoma (SCC) must be balanced with the potential for higher toxicity rates. We performed a retrospective review of our institutional experience. METHODS Patients 70 years or older with p16-positive oropharyngeal SCC treated with definit...

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Pre- and post-therapy nodal status equally affects survival of patients with oesophageal squamous cell carcinoma receiving preoperative chemoradiation.

Patients with deeply invading (T3-T4) oesophageal cancers usually receive chemoradiotherapy with or without surgery. However, the prognostic significance of pre-therapy and post-therapy lymph node (LN) status remains unclear. We studied 195 patients who received chemoradiotherapy for deeply invading oesophageal cancers (T3-4, N0-1, M0). Of these, 105 patients underwent surgery while 90 were tre...

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Definitive Chemoradiation for Resectable Esophageal Cancer

The salvage operation for esophageal cancer is one of the most interesting topics today among Japanese doctors treating this form of malignant tumor. This topic has been selected as the focus of symposia and panel discussions at many annual meetings of surgical-, esophageal-, or digestive-disease–related societies in Japan. In parallel, definitive chemoradiation therapy has recently shown progr...

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Outcomes of anal cancer treated with definitive IMRT-based chemoradiation

Objective Despite excellent long-term outcomes, definitive chemoradiation (CRT) for squamous cell carcinoma (SqCC) of the anal canal with traditional radiotherapy techniques results in significant morbidity. Accruing data supports intensity-modulated radiotherapy (IMRT)-based treatment, and we report our institutional experience using this approach. Methods We reviewed patients with nonmetastat...

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ژورنال

عنوان ژورنال: British Journal of Cancer

سال: 2004

ISSN: 0007-0920,1532-1827

DOI: 10.1038/sj.bjc.6601461